Project 7: Investigating the prodrome of type 1 diabetes in childhood as it presents to Primary Care to predict earlier diagnosis and reduce ketoacidosis at presentation, using pseudo-anonymised linked Primary and Secondary Care data.

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Funder: Novo Nordisk

Overview: The study detailed in the Novo Nordisk study protocol focused on using anonymized healthcare data to analyze treatment outcomes for patients with diabetes. It aimed to assess real-world clinical management, health outcomes, and associated costs for individuals using various therapies, including those developed by Novo Nordisk.

Why SAIL was valuable:

  • SAIL offered access to anonymized, longitudinal datasets from general practice, hospital admissions, and prescribing records.
  • SAIL enabled researchers to study diabetes management across a large and diverse population in Wales.
  • SAIL facilitated analysis of treatment patterns and outcomes outside the controlled environment of clinical trials, providing practical insights into everyday healthcare delivery.

Results:

  • The study identified key patterns in the use of diabetes treatments and their impacts on patient outcomes.
  • Findings demonstrated the effectiveness of specific treatment regimens, helping to inform clinical practice and healthcare policy.
  • Cost-effectiveness analyses provided insights into the financial implications of treatment options, supporting resource allocation decisions in healthcare systems.